{"id":1728,"date":"2026-10-06T12:55:55","date_gmt":"2026-10-06T12:55:55","guid":{"rendered":"https:\/\/dev.ich.org\/index.php\/guidelines\/e14\/"},"modified":"2026-10-06T12:55:55","modified_gmt":"2026-10-06T12:55:55","slug":"e14","status":"publish","type":"guideline","link":"https:\/\/dev.ich.org\/index.php\/guidelines\/e14\/","title":{"rendered":"E14 \u2013 The Clinical Evaluation of QT\/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs"},"content":{"rendered":"<p>The ICH harmonised Guideline was finalised under <em>Step 4 <\/em>in May 2005.<\/p>\n<p>This document provides recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the potential of a drug to delay cardiac repolarisation.<\/p>\n<p>This assessment should include testing the effects of new agents on the QT\/QTc interval as well as the collection of cardiovascular adverse events.<\/p>\n<p>The investigational approach used for a particular drug should be individualised, depending on the pharmacodynamic, pharmacokinetic, and safety characteristics of the product, as well as on its proposed clinical use.<\/p>\n<p>The assessment of the effects of drugs on cardiac repolarisation is the subject of active investigation.<\/p>\n<p>When additional data (non-clinical and clinical) are accumulated in the future, this document may be reevaluated and revised.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ICH harmonised Guideline was finalised under Step 4 in May 2005. This document provides recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","guideline_category":[9],"guideline_tag":[],"rd_phase":[],"class_list":["post-1728","guideline","type-guideline","status-publish","hentry","guideline_category-efficacy"],"acf":[],"_links":{"self":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline"}],"about":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/types\/guideline"}],"version-history":[{"count":0,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1728\/revisions"}],"wp:attachment":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/media?parent=1728"}],"wp:term":[{"taxonomy":"guideline_category","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_category?post=1728"},{"taxonomy":"guideline_tag","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_tag?post=1728"},{"taxonomy":"rd_phase","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/rd_phase?post=1728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}