{"id":1723,"date":"2026-10-06T12:55:53","date_gmt":"2026-10-06T12:55:53","guid":{"rendered":"https:\/\/dev.ich.org\/index.php\/guidelines\/e9-r1\/"},"modified":"2026-10-06T12:55:53","modified_gmt":"2026-10-06T12:55:53","slug":"e9-r1","status":"publish","type":"guideline","link":"https:\/\/dev.ich.org\/index.php\/guidelines\/e9-r1\/","title":{"rendered":"E9(R1) \u2013 Addendum: Statistical Principles for Clinical Trials"},"content":{"rendered":"<p>The Addendum provides clarification on E9 and an update on the choice of estimand in clinical trials to describe an agreed framework for planning, conducting and interpreting sensitivity analyses of clinical trial data. This Addendum focuses on statistical principles related to estimands and sensitivity analysis, not on the use or acceptability of specific statistical procedures or methods. The primary focus of the Addendum is on confirmatory clinical trials.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Addendum provides clarification on E9 and an update on the choice of estimand in clinical trials to describe an agreed framework for planning, conducting and interpreting sensitivity analyses of clinical trial data.\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","guideline_category":[9],"guideline_tag":[],"rd_phase":[],"class_list":["post-1723","guideline","type-guideline","status-publish","hentry","guideline_category-efficacy"],"acf":[],"_links":{"self":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline"}],"about":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/types\/guideline"}],"version-history":[{"count":0,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1723\/revisions"}],"wp:attachment":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/media?parent=1723"}],"wp:term":[{"taxonomy":"guideline_category","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_category?post=1723"},{"taxonomy":"guideline_tag","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_tag?post=1723"},{"taxonomy":"rd_phase","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/rd_phase?post=1723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}