{"id":1696,"date":"2026-10-06T12:40:51","date_gmt":"2026-10-06T12:40:51","guid":{"rendered":"https:\/\/dev.ich.org\/index.php\/guidelines\/s3a\/"},"modified":"2026-10-06T12:40:51","modified_gmt":"2026-10-06T12:40:51","slug":"s3a","status":"publish","type":"guideline","link":"https:\/\/dev.ich.org\/index.php\/guidelines\/s3a\/","title":{"rendered":"S3A \u2013 Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies"},"content":{"rendered":"<p>The ICH Harmonised Guideline was finalised under <em>Step 4<\/em> in October 1994. This document gives guidance on developing test strategies in toxicokinetics and highlights the need to integrate pharmacokinetics into toxicity testing, in order to aid in the interpretation of the toxicology findings and promote rational study design development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The ICH Harmonised Guideline was finalised under Step 4 in October 1994. This document gives guidance on developing test strategies in toxicokinetics and highlights the need to integrate pharmacokinetics into toxicity\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","guideline_category":[19],"guideline_tag":[],"rd_phase":[],"class_list":["post-1696","guideline","type-guideline","status-publish","hentry","guideline_category-safety"],"acf":[],"_links":{"self":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline"}],"about":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/types\/guideline"}],"version-history":[{"count":0,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline\/1696\/revisions"}],"wp:attachment":[{"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/media?parent=1696"}],"wp:term":[{"taxonomy":"guideline_category","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_category?post=1696"},{"taxonomy":"guideline_tag","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/guideline_tag?post=1696"},{"taxonomy":"rd_phase","embeddable":true,"href":"https:\/\/dev.ich.org\/index.php\/wp-json\/wp\/v2\/rd_phase?post=1696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}